3-Oxo Rosuvastatin Impurity Calcium Salt CAS 1346747-49-6(Free Acid)
| CAS No. | 1346747-49-6(Free Acid) |
| Molecular Formula | 2*C22H25FN3O6S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
3-Oxo Rosuvastatin Impurity Calcium Salt (C22H25FN3O6SCa) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 3-Oxo Rosuvastatin Impurity Calcium Salt (CAS 1346747-49-6(Free Acid)), a pharmacopoeial impurity reference standard (molecular formula C22H25FN3O6SCa, MW 518.59 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | 2*C22H25FN3O6S Ca |
| Molecular Weight | 518.59 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Oxo Standards
- Rosuvastatin Impurity 205 (CAS 1007871-85-3)
- Rosuvastatin EP Impurity L Calcium(Mixture of Diastereomers) (CAS 1024064-70-7)
- Rosuvastatin Impurity 267 (CAS 1031246-43-1)
- Rosuvastatin Impurity 19 (CAS 1035595-71-1)
- Rosuvastatin Impurity 27 (CAS 1044518-75-3)
- Rosuvastatin Impurity 192 (CAS 1092844-00-2)
- Rosuvastatin Impurity 123 (CAS 1112048-62-0)
- Rosuvastatin Impurity 37 (CAS 1197348-98-3)
Recommended Standards
- Bromfenac Impurity 62 (CAS CATO-C4X-200262)
- Idebenone Impurity 7 (CAS 319906-76-8)
- Trazodone Impurity 102 (CAS CATO-C4X-1772102)
- 4-((4-Amino-5,6-dichloropyrimidin-2-yl)amino)benzonitrile (CAS 269055-73-4)
- 1-Isobutylspiro[indoline-3,3'-pyrrolidin]-2-one (CAS 1422063-33-9)
- 2-Amino-4-chloro-6-methylpyrimidine-5-carbaldehyde (CAS 1378822-81-1)
- (4-pyrimidin-5-ylphenyl)methanol 198084-12-7 A813958 [4-(5-pyrimidinyl)phenyl]methanol (CAS 198084-12-7)
- Methyl 2-acetyl-6-formylisonicotinate (CAS 1393569-00-0)
- 4-Bromo-2,3-difluoro-N-isopropyl-6-nitroaniline (CAS 1365271-69-7)
- Glucagon receptor antagonists-2 (CAS 202917-18-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com